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Special Issue „Pathogenesis of Alzheimer’s Disease”

poniedziałek 28.09.2020

Dear Colleagues,

This special issue is focused on the effort to sum up contemporary knowledge referred to pathogenesis of Alzheimer’s Disease (AD). More than a century ago, German psychiatrist, professor of neuropathology, Alois Alzheimer described the most serious form of an age-related progressive neurodegenerative disorder in human beings. In the familial form, mutations in three major genes (amyloid precursor protein (APP) gene, presenilin1 (PSEN1) gene and presenilin 2 (PSEN2) gene are indicated. In turn, it is widely accepted that sporadic form of AD (more than 95% cases) is multifactorial and the prevalence is significantly higher at > 65 years and older. Overall, genetic complexity, epigenetic control and metabolic turmoils make the view of disease ambiguous and hard to find the causal relationships between different possible molecular etiologic factors. Extracellular senile plagues (beta-amyloid deposits), and intracellular neurofibrillary tangles (hyperphosphorylated tau-protein) are the most prominent characteristic markers of AD. Because of growing elderly the WHO prognosis for 2050 is more than 115 million individuals will be affected. The severity of AD is that affected people are sedentary and totally dependent on nursing care. Today, AD is the most expensive disease. 21st of September is the International Alzheimer’s Disease Day making this opportunity to encourage various specialists for submissions.

Prof. Dr. Arkadiusz Orzechowski
Prof. Agueda A. Rostagno
Guest Editors

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